Will over-pronation of the feet hurt me?

My feet do have an arch but they over pronate in and are constantly aching and my ankles hurt and I have to wear a knee brace when I run. I know that my arches will hurt me and have already started to but I was wondering if they can hurt me in any other places like my back and shoulders. Like causing problems; aching, tightening, pain. And if they will hurt me in other places, will they hurt me badly? Or is it something that I don’t need to worry about?
Thanks!!