How can we be certain the Uncertainty Principle is certain? (Strange Universe '11)

The Heisenberg uncertainty principle shows us that certain properties we wish to measure interact such that the more precisely we measure one of the properties, the less precisely can we know the other. Generally, this involves measuring tiny sub-atomic particles for their motion and positing. If we establish their motion precisely, we can only give a rough approximation of position and vice-versa. This may seem a trivial annoyance, but it has truly profound implications. In a deterministic universe, if we were able to establish the exact initial conditions at any one instant, we should be able, given a full set of laws, to calculate exactly what would come in the future. But because it is impossible to fully establish the initial conditions, because the uncertainty principle limits our precision, no such calculation can ever be done.

But if uncertainty is the rule, how may we be certain of that?

This is the second of the 2011 series of Strange Universe questions. Previously asked in the series:
1—How do you envision space in more than 3 dimensions, then rotate it to see what happens?
The entire 2010 Series of 20 questions can be found from here