This is an intensely controversial subject.
Many of the pros and cons have already been covered. I’d like to point out a few misconceptions.
@nikipedia
“The use and care of animals in research is very strictly regulated in all western countries”
In the United States, at least, the only Federal regulation on the welfare of lab animals is the Animal Welfare Act. The Act has some gaping holes. Most importantly, it does not cover rats and mice- which, as you know, are the vast majority of mammalian test subjects. It also doesn’t cover any non-mammalian vertebrates. It mandates only some very basic housing standards; it doesn’t in any way regulate what can be done to the animals.
The actual treatment of animals can be regulated by Institutional Animal Care and Use Committees (IACUCs). However, facilities that use AWA-exempt species aren’t required to have them.
Even those facilities that use AWA-covered species aren’t inspected very often- the inspection program is chronically underfunded and understaffed, and the inspectors are responsible for many other types of facilities as well.
So I believe that it’s false to say that animal research is tightly regulated.
On the other hand, I do not believe that scientists are sadists. Any one who has read my comments here knows that I am a huge supporter of science. I do believe that animals often suffer in research- not because scientists are wanton torturers, but because the animal is used as a tool, and not necessarily as a being deserving of rights. Much of the suffering is behavioral, as animal housing frequently doesn’t allow for species-typical behavior.
As far as the validity of animal testing- there is no doubt that both animals and humans have benefited a great deal from animal research. Note, however, that the benefits do not automatically make such testing ethically correct. It’s also clear that animal testing has often been inaccurate. This, for example, is a fascinating podcast from Skeptic’s Guide to the Universe on the subject of whether animal testing is predictive of human response.
Whatever the ethical position one takes, the reality is that laboratory research on animals isn’t going to end any time soon. So what do I believe should be the legal mandates in the US?
• All vertebrate animals should be covered by the Animal Welfare Act.
• The Act should be updated to reflect the latest behavioral research on animal subjects and stress, to mandate housing and handling conditions to reduce stress as much as possible. Research should be done on pain and stress perception and alleviation in all test species, and methods developed to alleviate pain and stress. All research protocols should directly address what painful and stressful situations (including behavioral stressors) the animals will experience, and how they will be alleviated.
• All Federally-funded research facilities should be required to have an IACUC, and all meetings should be open to the public.
• The Act should be fully-funded so that all facilities are inspected at least yearly.
• Research should be emphasized that looks at mathematical models to determine what the smallest numbers of animals needed is in order for test results to be valid, and at other procedures to reduce the number of animals used.
• Test facilities should sponsor adoption of those lab animals, such as dogs, cats and rabbits, that could potentially make good pets and are used in non-fatal studies, after those studies are over.
• Research facilities and the government should also sponsor retirement facilities for all primates, such as currently exist for chimpanzees.