Cat owners, can you help me?

It’s possible that one is sick, and the acting out is stressing the other cat out. It could be behavioral, especially if you have stray cats (whether you know it, or not) hanging around outside of your house. Particularly by the doors or windows. If you have stray cats in heat hanging out around your house, it’s even more likely that your cats will be stressed.

That’s very interesting @DigitalBlue , and here’s something else I should have mentioned in the original question. They have both suddenly become very vocal, and by that, I mean that they basically wander around crying. I feel horrible for them, and try to offer them solace and cuddles, and they purr when I do, but I don’t think that’s really doing the trick.

Is it possible that there are any local stray female cats hanging around? It sort of sounds like they’ve scented a female in heat.

@WillWorkForChocolate , Well, I have encountered a problem with a female cat (in heat) hanging around prior to these last few days (it was about one month ago), I had the sliding glass door open and this little girl cat would come prancing around and Bob would literally lose his mind (even though he’s neutered!). He was like a different cat. He was growling at me, daring me to touch him and even scratched me when I tried to remove him from the situation. But he never, ever pooped where he wasn’t supposed to.

I would watch for her (and others.) Strays in heat hanging out around my house drove my indoor cats absolutely nuts, at one point one of my boys started to spray under the window, although he is neutered.
My mom’s cats started urinating and defecating in the house, and she couldn’t figure out why… a few days later she noticed someone else’s cat hanging out around the house. At one point the cat (not her cat) walked up and sprayed right on the front door.
I can’t promise that is an issue, it’s always good to rule out health troubles, but it’s pretty common as far as I know.

Are they neutered? If not, get it done ASAP.

When my son was 4 years old, our new cat went into heat. We told him to be sure not to let the cat out for that reason. But he did, explaining, “I know you said not to let Mandy out because it was so hot out, but she was meowing because she wanted to be with her friends. So I let her out.” Mandy found herself at the clinic as soon as she got back.

This is unlikely, but I’ve heard of animals behaving strangely before natural phenomena, and that leaped into my overactive imagination as a possible cause. If you live in an area where there are earthquakes, that is possible.

@Sunny2 “because it was so hot out”, lol!

TY to all who answered my original question, and I think I have narrowed down the problem! Neither one of my cats have ever been outside, so they’re really not in danger of getting fleas. However, I live at the beach and constantly bring in small amounts of sand on my shoes. And guess what sand has crawling around in it? FLEAS (ick, makes my skin itch just thinking about it). Therefore, I suppose I just invited the fleas right on in!

So last night I took the brush to both of them and, sure enough, they had fleas. Needless to say, I was at the vet first thing this morning to pick up some Assurity. I treated them both at approximately 10:30, it’s now noon, and they’re already starting to act like the normal boys they are. Thank God that’s over!

I’m going to make certain I leave my shoes outside the door from here on out, to avoid this happening again.