How does a spider bite lead to death in humans?

Spider bites can cause necrotitis. Hanneman had Necrotizing fasciitis, a disease causing death to his cells and killing his tissue. The toxins associated with diseases like that can overwhelm the liver.

Allergic reaction/toxic shock.

The liver filters toxins from your body, so without spending too much time on this, I’d say the spider toxin had already spread throughout the body. We have brown recluses spiders and people have been known to have big holes in their flesh after a bite that they didn’t get taken care of immediately.

Like you go to bed, and there’s on in your blankets. You put on your robe and there’s one in your sleeve. Our hillbilly cure is shaking the covers out before bed, shaking out your robe, checking shoes before putting them on, and of course, lots of spray to kill the buggers – I was raised that way and never take chances.

He left it untreated for a long time. He developed necrotizing fasciitis a long time ago.

Relevant

But, he claimed he was over that months ago. The liver failure was mostly due to the gallons and gallons of various substances commonly ingested by rock stars. He was on a liver transplant list, mostly due to Vodka breakfasts for 20+ years. He quit drinking, and then he died.

This site (The Gauntlet) suggests Hanneman died of alcoholic liver disease.

Some spider bites release powerful enzyme toxins that are destructive enough to cause large, ulcerating wounds with necrosis (death of tissue) that overwhelms the body’s ability to fight it. This in turn may progress to necrotizing fasciitis requiring skin grafting after cutting away large pieces of flesh – even amputation of a limb. Concomitant severe systemic reaction can cause death via shutdown of the kidneys, though that’s pretty unusual in a full-sized adult, I think.

I’ve never heard of death from spider bite, although I’m sure there are some reported cases. It is so rare that I question the commonly held belief that this death was from a spider bite. I’ve certainly never seen a case.

If it was, and I’m not saying it was, from what I can gather is that he had a bad infection on his arm after a bite and he didn’t seek medical treatment. What is more probable is that this supposed bite got infected, and he developed a necrotizing infection not from the bite, but from the superinfection.

I see a lot of people with infections that they say were from “spider bites” but they’re most often not a spider but something else. People can develop skin infections from a whole slew of reasons, and they just automatically associate it with a spider they saw.