Could ankle swelling and thigh pain be related?

My left ankle has been swollen by the end of the day for a few weeks now (starts out normal). I also just got a stabbing pain in the front inner thigh on the left leg. Could these be related, or just a coincidence. I believe the ankle swelling started the night we did relay for life. I noticed in the wee hours of the morning that my ankle was swollen. It has also been swollen almost every evening since then. The pain in my thigh was sudden onset and a sharp stabbing pain. I do have hip and knee problems as well that have been going on for about 12 years. Any help would be appreciated.