What does a caregiver for someone with multiple sclerosis need to know?

I have a good friend with Devics syndrome which is similar to MS.
It is neurological in nature and attacks the spinal cord and depending on where the attacks occur can lead to paralysis, respiratory failure, all sorts of awful things. She has chronic pain and often depression along with side effects from all the different drugs they like to guinea pig people with.
I’d say that the pain factor, energy factors and emotional ups and downs are the biggies.

Physically, depending on the level of disability proper bed care, transferring and watching out for bed sores that can become septic in a bedridden person are tantamount.
Mentally and emotionally allow the person to feel it’s okay to complain about their pain and feel down. My friend is struggling with this as she doesn’t want to be a complainer but also needs emotional support and extra caring at times.