Could your body accept its old organ without anti-rejection medication after it's been in another body?

Yes, I don’t think it would have been changed. It does seem highly unlikely though.

“Transplant rejection is caused by the body’s immune response to foreign material. The body naturally tends to attempt to destroy encountered foreign matter. As a result, those who receive transplants are given transplant rejection medications that reduce the body’s immune response.”

Source

Yeah but since it has been “contaminated” in a different body don’t you think it my have gone through some changes?
Where’s Shilolo when you need him?

Depends. Some organs will harbor lymphocytes for a long period of time. Theorectically, an organ can be returned to your own body, with the previous hosts lymphocytes, and then those lymphocytes will start attacking you – your old organ will reject you.

And you thought the wrath of a woman scorned was bad.

@astrocuck what am i chopped liver?

(no offence shilolo you rock!)

None taken. Great answer by the way, though graft-versus-host disease (GVHD) is typically a “problem” of bone marrow transplants (BMT) and not solid organ transplants. I put the word “problem” in quotes, because a small amount of GVHD is probably an important component of the success of BMT (the new, healthy bone marrow continually attacks the original, unhealthy, malignant bone marrow).

Sorry. I thought drhat77 was just a clever handle.
Now, what the hell are you saying? It is possible in some situations to do without the medication?

Two docs?. That means that we can now get second opinions.

@drhat77: you’ll have to go some to beat shilolo’s avatar. His gets best-in-breed (even tho at first I thought he was a conehead.)

theoretically no.
In practice they would follow the ussual protocol and administer the anti rejections meds altering the dose till they have the minimum required to maintain adequate renal function.

@astrochuck there isn’t a likely scenario where you’d have your own organ returned to you, but i think if it happened they wouldn’t start out with anti-rejection meds. if for some reason the previous hosts lymphocytes attacked you, then they might put you on antirejection meds

I realize this scenario is purely hypothetical. But strange situations do tend to present themselves all the time. I’ve heard of stranger things that have happened.