Has anyone tried adding more amyloid-beta to see what happens in Alzheimer’s disease?

Okay, I am not very good with chemistry and such, so that was a bit difficult to understood.
However….if I am understanding all this right; the plaques that are part of what causes Alzheimer’s are made of Amyloid-Beta. So, I am not getting why adding more would be beneficial.

@anniereborn To see the correlation between amyloid-beta and Alzheimer’s disease. Would more make someone worse or better or no correlation? Not just for shits and giggles. If no correlation then resources can be better spent from square one.

Well it causes the disease so more would probably be bad, not good.

@Darth_Algar I would like to see the research. Amyloid-beta isn’t 100% guilty , so I would like a test to see the correlation.

@RedDeerGuy1 …Amyloid-beta isn’t 100% guilty

Although the mechanism by which A Beta interacts and if it is causal for Alzheimers, it is definitely correlative, in that A Beta plaque is one way that a patient is identified as having Alzheimers.

There is a lot of research focus on how the protein interferes with brain messaging.

Introducing more A beta would be unethical, like trying to trigger an immune response in an AIDS patient by infusing more viral load.

@zenvelo I disagree. It would be a simple test on mice to see what happens. I’m surprised that no one has tried it yet. All Avenues should be considered for this horrible condition. Novel ideas should be welcome.

@RedDeerGuy1 Yeh, animal experiments (as much as I hate them) have advanced medicine greatly. But I’m not sure this would truly translate well to humans.

There have been trials. Here’s some light reading for you: https://scholar.google.no/scholar?q=amyloid+beta+clinical+trials&hl=no&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwi1mYik05nTAhVEYZoKHQvzBfcQgQMIGDAA

I put “alzheimer disease” AND “amyloid beta protein” into PubMed and got 10759 results. This means that a fair bit of research has been done in this area.

@RedDeerGuy1

The research has been done. I know the popular thing these days is to assume that as laypeople we know more than the folks who devote their lives to whatever field, but it just isn’t so

@Darth_Algar Thanks. Just trying to see where I can help and have fun.