Steven-Johnson syndrome, also very similar TENS (they are basically the same thing) can happen with every and any medication. Literally, all medications have this risk. Some have shown higher incidences than others. This is why ALL medications have a warning to contact your doctor if you see a rash. My sister worked on a burn unit for a few years and one woman got it from Tynelol. That’s extremely rare. In fact, getting the condition at all is extremely rare, which is why most people have no idea what it is.
No, I don’t worry about severe reactions when taking antibiotics to answer your questions, and I am allergic to sulfa antibiotics (I get a rash, but was not to the level of TENS) and I get a horrible reaction to clindamyacin (burning skin and like an elephant is sitting on my chest).
Meanwhile, I unfortunately have had to take many antibiotics and I’m fine on the vast majority of them. I even take quinolones, and all over the internet are horror stories about quinolones, and social media needs to shut the hell up about it. Lay people scaring people, and it’s over the top and out of proportion. Even people who blah on about how horrible they are don’t even realize they take them! Both Cipro and Levaquin are quinolones, and prescribed all the time.
If you experience a serious reaction, but not ER worthy, just call your doctor and get your meds switched.
You have taken a lot of antibiotics the last couple of years if I remember correctly, and you are fine. Remember that, you’re history is you’re fine.
I do try to take my first pill of a new medication when others are around. My husband, or in a public place.
Edit: The drug you are taking is in the erythromycin family, a macrolide, and those are usually tolerated very well.