I can think of a few times when this sort of this is something I’ve done.
“Do you think you, as a friend, wouldn’t ask for a certain favor, that you know the other friend wouldn’t want to do, shouldn’t do, etc.?”
Ideally, and I have not asked favors for such considerations. But I have also asked (and been asked) for favors that I realize (usually in hindsight) that there were good reasons not to ask.
So the answer is sometimes yes, sometimes no.
In practice, hindsight has seemed to make clearer to me what the reasons were NOT to ask, especially after the friend declined the request. When I’ve asked for such things, I have not been clear-minded about whether it was appropriate to ask or not.
“Furthermore, if you ASK, for this said favor, do you think, if (s)he refuses, that you wouldn’t hold him/her responsible for it?)”
I don’t think I’ve held friends responsible for saying no.
In at least one case, the reaction greatly affected the friendship, and I suppose I did hold them somewhat (but mostly myself) responsible for that.
I also had friends ask me for things that I knew they should not have, and that to one degree or another I think they did too. I’ve both said yes and no. Saying no was usually the better the choice, and more so the more wrong the request was.
When I was maybe 6 years old, a friend asked me for my tricycle. I said no. He persisted and I said no. He said he would take it and tell people I gave it to him. I said heck no. He tried to take it from me physically and I yanked it away from him and yelled at him. I should have realized he was a terrible “friend” at that point and had nothing to do with him. In practice, it took later incidents to clarify for me how terrible a “friend” he was, and to be done with him.
I had several such incidents when I was 4 to 11 or so years old, and they helped clarify several things about boundaries and caution in friendship.
I still have some people whom I could ask or do unreasonable things for, but that would almost never happen now because even if/when we start to talk about some unreasonable request, usually more reasonable reflections and support are offered instead.
And I now avoid friendships with crazy people.