I guess I should answer my own question. These are the changes I’d make to baseline human across the board, irrespective of any additional changes each individual may choose to make themselves:
- Eyes which see into the deep infra-red and ultraviolet, all the way down to radio and up to x-rays.
- Senses which can be deactivated at will, with cut-off nodes at nerve junctures. So you should be able to close your ears or shut off your tongue, and you should also be able to deactivate both the sense of touch and pain sensation at each nerve cluster to allow oneself to turn off pain to specific regions.
- Voluntary thermoregulation and digestion. You should be able to set your internal thermostat higher or lower according to preference, so you can feel toasty warm walking naked in a snowstorm if you can afford the extra calories. Digestion should likewise be optional, so that food and liquid can be held internally without digesting if desired, then the processing switched on when it’s needed or convenient.
- Externally-triggered body regrowth. The problem with having people restore themselves starfish-like automatically is you end up constantly teething, constantly regrowing hymens and foreskins, and undoing plastic surgery for conditions like a harelip. Therefore there should be some simple enzyme used as a trigger for regrowth, which would occur only in the presence of that enzyme.
- Rapid (de-)pigmentation. Melanin production should be triggered on an emergency basis when exposed to dangerous levels of UV radiation. Tans should occur nearly instantly, with high-UV exposure turning people completely black. On the other hand, in the absence of such exposure, pigment should drain rapidly to translucency to maximize vitamin D production.
- A universal blood interface port. To facilitate medical treatment, a port somewhere on the body should provide direct access to the circulatory system without the need to break the skin.
- Neonatal androgyny. Humans should be able to hedge their bets, being intersexed until adulthood, when each person can choose the sex of their preference—or choose to remain intersexed.
- A kill switch. Humans should have the power to choose to die at any time simply by willing it so.
- A one-way immortality trigger. It should be possible to choose to stop aging, but only at the cost of permanently destroying reproductive ability. Likewise, giving birth (or having viable sperm ejaculations) should permanently disable the ability to stop aging. You can reproduce or become biologically immortal, but not both.
There are a lot more changes I’d make to my own body, but these are things I think should be bred into the mainline of human genetics.