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Why does the Moderna and Pfizer vaccine need to be kept at sub zero temperatures?

Asked by JLeslie (65980points) December 14th, 2020 from iPhone

What part of the vaccine decays (if that’s the right word) when it hits warmer temperatures?

Also, could they use preservatives and get around the necessity for the cold temperatures?

I heard Moderna doesn’t need to be kept as cold as Pfizer. Why would that be if they are made from similar materials.

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