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JLeslie's avatar

Can you explain gene regulating proteins to me like I’m in the 5th grade?

Asked by JLeslie (65758points) July 6th, 2023 from iPhone

A friend of mine was recently diagnosed with Glioblastoma. It’s a very aggressive brain cancer.

A different friend of mine just sent me an article about some research being done. The article states that The reactivation of a dormant retrovirus, HML-2, may contribute to the aggressiveness of glioblastoma, a type of brain tumor.

Researchers discovered that the virus influences the stemcell state of the tumors, thereby promoting a more resistant form of cancer. HML-2 was found to affect stem cell programming via a gene-regulating protein named OCT4.

If the above is true, does that mean the virus is contagious and only people with the right genes would have a problem? Or, the right protein to activate the gene? Where does the protein come from?

Is the gene in the person from birth, or it’s a gene in the cancer?

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Lightlyseared's avatar

Proteins are large molecules made up of chains of smaller molecules called amino acids. )
There are 20 amino acids. Think of amino acids as letters and DNA as a recipe book that has the letters of proteins in the correct order the body needs to put them together to make each specific protein. If the body wants to make insulin the body looks at the DNA for insulin and uses it to make insulin.
A gene regulating protein is something that interacts with DNA to either stop the body making the protein or to make it more likely the protein is made. For example it could atache its self to the DNA on top of the recipe and stop the recipe from being made.

Now to answer the question in the details… Take HIV. Viruses are basically nothing more than a string of DNA that ‘hijack’ a cells ability to make proteins in order to make copies of themselves. HIV is a retrovirus so instead of DNA it is RNA. This is a mirror image of the instructions in DNA. For the body to make copies of retrovisues they need to translate the RNA back to DNA and thing that does this is a protein called reverse transcriptase. Humans dont need this protein, it doesn’t do anything useful, but some (well, most) people have copies of it in the ‘junk’ DNA and HIV uses this to infect people. If someone doesnt have thisin their DNA or if it has not been “expressed” (ie used to make reverse transcriptase) then they can’t be infected with JHIV

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JLeslie's avatar

@Lightlyseared The article said a “dormant retrovirus.” Do they mean already in the body? HIV isn’t pre-existing in the body.

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JLeslie's avatar

Just adding I know some of the basics of DNA like ATCG and DNA basically is our genetic code while RNA is the communicator I guess? High school biology so it’s been a long time.

Also, I understand amino acids are the building blocks of protein.

I understand HIV duplicates using our cells.

After that I get confused.

My girlfriend did 23 and Me years ago. Can they check for this trait in her genome?

longgone's avatar

[mod says] The OP can choose freely whether to put their question in the Social or the General section. One reason Social might work better is that it can be helpful to allow some meandering because that fosters an environment of creative thinking.

Even in Social, responses need to be respectful. They also need to relate to the discussion. Here’s a link to the relevant section of the Guidelines.

It’s very unusual for us to remove so many responses on a Social thread. Please carry on with the discussion without further derailing. If you have any more questions, feel free to PM a mod.

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