Best way to get downtown from Telegraph Hill?

If you want to take public transit, you could take the F Line from Embarcadero & Bay to Market & Kearny or pick up the #45 bus at Union & Columbus to Stockton & Geary.

I would recommend riding a bike to work. It’ll be mostly downhill on your way to work (so you won’t work up too much of a sweat), and you’ll get a great workout on your way home.

the 45 bus.. also, take a look at www.hopstop.com

Two of my coworkers live right near there, and our office is on 2nd and market, so it’s pretty much the same commute. They both walk to work…it’s definitely acceptable to SF to wear sneakers to work and then change when you get to the office.