Most lucrative (non-programming) software specializations?

A cousin of mine recently graduated with a degree in English. She’s bright and seeking a first job but has no particular industry of interest. She’s adept at math and writing and I suggested she explore certifications or just becoming highly proficient, without a formal credential, in a particular software package. She asked which one, to which I responded I wasn’t sure, but would research it.

I was thinking along the lines of AutoCAD, Peachtree, InDesign, or maybe even more esoteric software, like financial modeling, ERP, CRM, eletronic medical records systems, and the like.

It seems like there’s a zone somewhere between MS Office software, and SAP, where many, many non-programming professionals find their niches. Does anyone have suggestion on where to look for these types of programs that are in demand, concrete trends, or have friends/family whose careers largely center on particular expertise with a brand/class of software product?