I may be different, and maybe not (there’s some thought that depression is a unipolar version of bipolar disorder). For bipolar, they try to provide a mood stabilizer (which constrains the magnitude of your changes) and then an anti-depressant, if needed.
My first mood stabilizer was Lithium. It got rid of my mania (which it is really good at) and reduced the length of my depressions (but not the severity or depth). It has numerous side effects, and I’ve got most of them: shaky hands, skin itching (like crazy), weight gain, and thought slowness or difficulties with memory (it can be hard for me to retrieve random words).
SO they added Buproprion (Wellbutrin), an antidepressant to try to help with my remaining depression. It helped, but I constantly felt like I was just beneath the surface of the water.
At last, to help with Lithium side effects, they have added another mood stabilizer (the one my cousin and aunt are on) called Lamictal. This allowed me to reduce my Lithium (my hands shake less). It is supposed to be better at helping with depression than Lithium, which is good at stopping manias. It supposedly has no side effects, except there is the possibility of a skin rash that can kill you. But that happens in only one in five thousand people.
They’ve been slowly ramping up my dose (to see if I’m allergic), and I’m about halfway through that process. I’m not at a therapeutic dose yet. However, I am strongly susceptible to suggestion (by a medical professional, not anyone else, you goofballs :D) it may be working already. We’ll see.
I, too, was resistant to the idea of medicating depression. Then I got really, really sick, and nearly died, and that made me reevaluate my position. I still struggle with it. I blame myself for my illness, and for not getting better, faster. I guess I would urge folks to realize that resistance to these drugs is really based on shame, and it is a foolish shame. Of course, I’m telling myself the same thing. We’ll how long I believe it.