What would be the best way to clean a down comforter bed sheet with puke on it for a full day?

Scrape off all that you can into the trash can. If your washing machine is large enough you can throw it in there. If not, take it to a laundromat with ‘commercial size’ washers. It can be washed in warm water, on the gentle cycle. Put the soap in and let the washer fill up about half-way before adding the comforter, so the soap is mixed in. Then dry it on low heat (it will take a while). I always lay mine over a couple of kitchen chairs to air dry for a while after that.

I would do as @augustlan recommends but I would also add oxyclean to this (ewww).

Throw it away.

I would do what PupnTaco says. It is how I clean most things.

Boys. Sigh.

No Kidding.

Seriously, if the bile has soaked into the down feathers, it’s trash.

Ok, you do have a point there.

Cleaning a down comforter is not the problem. Drying it is. If you are not careful the down will clump together.

use borax when washing this will get rid of smells and stains and is 100% natural
if it turns out that the feathers clump when dried throw it out or soak it again and hang out to dry . there is a way to dry feathers

Put a couple of tennis balls in the dryer with the comforter. It will be noisy, but it stops the clumping.

So will a sneaker. But why not stop drinking and use the money you save to buy a new comforter? This time don’t buy down but a microfiber.