Genetic outcome from human couple with DNA defects?

Asked by eno_detah (39

) September 22nd, 2009

What are the likely congenital defects and/or inherited chromosome abnormalities (and percent likelihood of each) if a male and female human with Robertsonian translocations of 13 and 22, respectively were to have offspring?

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5 Answers

If a parent, no matter the gender, has offspring it has a 100 % chance the the baby wil have Down syndrome.

CMaz (26313

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Is this a homework question? Because Flutherites aren’t fond of doing your homework for you. :)

evegrimm (3714

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this or this

eponymoushipster (20307

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Unfortunately any offspring from even just one parent with such translocation would most likely not be viable (miscarriage). The parent with a Robertsonian translocation has reciprocal changes in their chromosomes so that they are uneffected phenotypically(in the case of a 13:22 traslocation), but they will be unable to “donate” a full set of normal chromosomes for meiosis to occur.

There is a good paper about 13:22 translocations, as it is not the most common type of translocation and not much research has been done in this area. paper

Also, if this is a true scenario (not just homework) then it would be advisable to speak with a genetic counselor to fully understand this genetic condition.

limegwri (140

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