@Val123 – Yes. But if we’re looking for an ultimate answer, we would either have to ask the lawmaker of the universe or assume the universe/multiverse by itself simply had no other choice but to put the natural laws in place the way they are.
Of course the better our comprehensive understanding of all natural laws get the more we are able to explain particular parts as a result of more fundamental laws. A quantum theory of gravity might better explain why E=mc2. As explained by the Wikipedia article referred to by @andrew
“the concept of mass–energy equivalence unites the concepts of conservation of mass and conservation of energy, allowing rest mass to be converted to other forms of energy, like kinetic energy, heat, or light. Kinetic energy or light can also be converted to particles which have mass. The total amount of mass–energy in a closed system remains constant because energy cannot be created or destroyed and, in all of its forms, trapped energy has mass”
which means Einstein’s formula combines earlier know laws like the conservation of energy related to the first law of thermodynamics.
But we have to keep in mind that any theory describing the real world has to rely on a number of “axioms” i.e. stuff considered to be either self-evident. A given. Then there are “theorems” which can be deduced from “axioms”. Like for math, physicists want to come up with a minimal set of simple, beautiful “axioms” from which everything else can be deduced without contradictions. For the four elementary forces plenty of work has still to be done. Einstein’s general relativity and quantum mechanics contradict each other.
For the fundamental units (see SI, the international system of measurement) all we need are the following 7 units: meter, kilogram, second, ampere, kelvin, candela, mole. Everything else can be deduced for example volt, joule, watt, newton, pascal and so forth.