Is the (exaggerated) pursuit of pleasure ironically amplifying misery?

Daniel Kahneman, a Princeton University psychologist, talks about ‘hedonic treadmills’ leading to misery and depression.

David Myers, a Michigan Hope College psychologist, talks about an American paradox which includes spiritual hunger in an age of plenty.

Barry Schwartz, a Swarthmore College psychologist, talks about the problem of choice overload and excessive individualism. In one of his books he mentions an interesting statistic:

The rate of depression among the Amish in Lancaster County, Pennsylvania is less than 20% of the American average. Can this be related to significant communal obligations? A lack of choice overload? Or their limited pursuit of pleasure and the absence of hedonic treadmills? Is there less peer pressure? Or is genetics the explanation (fewer depression-related genes)?

What do you think about the pursuit of pleasure? Its rewards and its dangers?