Is there a website where two people in separate locations can play a game together?

omg where have you been for the last twenty years lol!

games.yahoo.com
twoplayergames.org
popcap

are but a few!

pogo.com
coffeebreakarcade.com

Some IM clients such as AIM, Yahoo Messenger, etc have games built in (same with skype)

My family and I use something called Hamachi to play games with a simulated LAN.

Windows messenger will do that.
One of my favorites is Isketch.com It’s like pictionary.

Gamecolonly is good for cribbage and backgammon. There are many other games as well, but I always find a player on this site. It’s free.

You already have a lot of suggestions. I play wordscraper on facebook, it’s just like scrabble. Also, I see you are in PA, not sure if you are western or eastern? If you live in western PA you might play eucre, there are sites for that also.

facebook has a fre applications that mean you can play games over a distance, msn has a few games too.

WOW – thanks everyone! I had no idea there were so many!