Would you be comfortable in an 800 sq.ft. house?

I’ve been researching small houses and micro-houses and think they are so cool. I know the current trend for the US is houses to be over 2400 sq.ft. I grew up in a large house, 4000 sq. ft. on a 3 acre lot. I have a wife and 3 children and we’re very comfortable in a 1500 sq. ft. house on ¼ acre. After we retire and the kids are gone I think I’d rather have less house and more yard. What are your thoughts on small and micro houses?